Available Digital Archives | 4264 total results

Shwachman-Diamond Syndrome (SDS) is a recessively inherited disease that affects patients' bone marrow health and white blood cell count, often leading to secondary illnesses like myelodysplasia and acute myeloid leukemia. Long-term damage to the central nervous system, skeletal muscles, and repetitive infections usually lead to premature death. The most common mutation in SDS patients disrupts a splice site (SS) in the SBDS gene. We hypothesized that the recently developed gene editing technique, Twin Prime Editing (TwinPE), could be used to insert a functional SS and correct SBDS splicing. Editing was initiated using plasmid delivery of the prime editor and two epegRNAs targeting an SBDStransgene in HEK 293Tcells. We had two designs for assessing editing efficiencies that consider either location of insertion site or insertion sequence content. We screened guides targeting different points within intron 2 that made different indellengths. Then, we tested insertion of sequences flanking the SS that were modeled after other genes' intronic sequences. The editing frequencies and splicing of SBDS were quantified using Sanger sequencing and qPCR. Using TwinPE, editing of the reporter led to over 200-fold increase in splicing, but expression was still lower compared to the original PE method inserting the same strong SS. Introduction of intronic sequences from other genes did not increase splicing further. These data suggest that TwinPE can be used to correct the SDS splice mutation. We plan to test TwinPE in primary HSPCs and will determine if these SBDS expression levels rescue the molecular defects of SDS.

Although hip-hop is often times depicted as something that is dangerous and full of crime, its listeners, and especially those who grew up in contemporary urban America see the artform as something beautiful and a beacon of hope. Biggie Smalls was a "hero." Many brought their children to the procession, and for youth like Karla Boston, an ll-year-old who went to the parade with her classmates claimed, "He was kind of a role model to all of us ... He found it to the big leagues. He found a way to get out of this neighborhood." This represents the oppression and economic or systematic inequalities that people of color and those who grow up in urban centers face. A funeral procession was turned into mass arrests and a feud between the community and authority. Hip-hop stands for more than just music and B.I.G's "final ride" shows what hip-hop means to its listeners, especially during its golden age in the 1990s. Hip-hop is a space to express urban realities and inequalities, and its delegitimization and nontraditional practices are responsible for its rise as a social power in the United States of America

Chart that shows the process of isolating red blood cells using the EVs Using the Beckman CytoFLEX SRT Sorter

Is the portrayal of professional basketball players different for female and male athletes? An examination ofESPN's social media posts during the WNBA & NBA 2022 Finals. This study enriches the narrative around understanding gender differences in sports marketing by extending the literature by presenting insight into understanding the media's portrayal of gender surrounding professional basketball through an American lens. This study examines how ESPN and other sport Instagram accounts, portrayed their male and female athlete during the 2022 WNBA & NBA Finals. Results indicate posts were fairly evenly when it came to male and female posts with some interesting themes being portrayed across the board.

Across the country, collegiate athletics have forever changed after mental health became a forefront issue after COVID-19. While many colleges are starting to address the issue of mental health stigmas present in athletics, it was proposed to conduct a research study on how Emmanuel College is handling the topic of mental health for their student-athletes. A survey was sent to the all student-athletes at Emmanuel College with the purpose of collecting qualitative and quantitative data, to address how different organizational structures (athletes, coaches, administrators) affected/addressed student-athletes mental health on campus. Results demonstrated that athletes are aware of help available, but are hesitant to address their mental health with professionals. In addition to this, the study revealed that coaches who lead under an autocratic leadership style have an increased amount of student-athletes who suffer from mental health issues, or have entertained quitting. Lastly, administrators were found to not have enough of a presence with their athletes when it came to advocating for mental health in athletics. Given that only 67 out of the 140 athletes at Emmanuel responded and completed the survey, results would be more accurate if 75-100% of the student-athlete population were able to complete a survey.

Marquee for MacBeth by the Emmanuel College Performing Arts Department released in Fall 2022.

Marquee for Stop Kissing by the Emmanuel College Performing Arts Department in Fall 2021.

Program for Oedipus Rex, a production by the Emmanuel College Performing Arts Department

Marquee for Buried Child by the Emmanuel College Performing Arts Department in February 2022.

Marquee for MacBeth by the Emmanuel College Performing Arts Department in Fall 2022.

Program that list the schedule of games that will be played during tip off weekend along with the names of basketball plyers, related events ans sponsers. The program was issued on November 19, 2022

When the emigration pattern from Ireland to America began it was almost exclusive amongst the single Irish male. It was difficult to be Irish in America, as Americans viewed the ethnicity negatively. They did not like the Irish man, they found their mannerisms and hobbies insulting and their religion, Catholicism, offensive. For this reason, few single Irish women emigrated to America in the years prior to the Irish Famine. The women were satisfied with their lives in Ireland and did not feel the need to subject themselves to a lifetime of prejudice in a foreign land. Disapproval of the ethnic group, combined with slow migration patterns, meant that there were very few support networks available in America for a single immigrant Irish woman. The opportunities available for the women in Ireland, combined with the lack of opportunities in America discouraged female migration in the years before the Irish famine. However, once the potato famine struck, life for women was disrupted which forced them to explore greater and different opportunities than those available to them in Ireland. This exploration of something greater resulted in mass female emigration beginning during the famine years and exploding in the century succeeding it. Through American letters, chain migration, a promise of greater employment opportunities, and the formation of a community of Irish Catholic immigrants in America Irish women sailed across the Atlantic in pursuit of liberty, love, and social mobility.

Emmanuel News covered the academic, cultural and social events of the College. This issue was released in February 2007

Emmanuel News covered the academic, cultural and social events of the College. This issue was released in October 2007

The magazine covers alumni, events, faculty members, students and features of interests at Emmanuel College. This edition was released in winter 2020. Stories of interest in this issue are the College's centennial and the 4oth anniversary of Sr. Janet Eisner's presidency

Students paint a still life of a female figure in an the Administration Building art studio in winter 1957

Archbishop of Boston, Richard James Cardinal Cushing, lays the final brick into place at the dedication of Marian Hall on September 26, 1955.

Archbishop of Boston, Richard James Cardinal Cushing, blesses the new student union at the dedication of Marian Hall on September 26, 1955.

Archbishop of Boston, Richard James Cardinal Cushing, hands over the keys to the student union building to Sister Provincial Loretto Julia Carroll, SND at the dedication of Marian Hall on September 26, 1955.

Learning Commons Newsletter is a staff periodical that discusses and highlights new programs, events and other community points of interest.

Transcript of Commencement Speech by N. Kleniewski

Program for Commencement Events for the Class of 2020

Transcript of Commencement Speech by Gianna Kittle

Schedule for Commencement Events for Class of 2020

Transcript of Commencement Speech by Bruce French

Baccalaureate Address by President Sister Janet Eisner

Commencement address by Sister Janet Eisner

Transcript of Commencement Speech by Margaret McKenna

Program for Commencement Events

Commencement Speech by D. Griffith given on May 22, 2021

Program of the May 14, 2022 commencement ceremony that includes order of exercise and a list of graduates

Program from the liturgy mass celebrating students attainment of bachelor degrees on May 21, 2022

Invitation to the Emmanuel College commencement ceremony on May 14, 2022

Commencement Address by Sr. Janet Eisner to the class of 2022 that was issued on May 14, 2022

Program for Baccalaureate Mass

Program from the liturgy mass celebrating students attainment of bachelor degrees on May 12, 2023

Pamphlet for the nursing pinning ceremony that took place on May, 12, 2023 at Emmanuel College.

Learning Commons Newsletter is a staff periodical that discusses and highlights, new programs, events and other community points of interest.

Learning Commons Newsletter is a staff periodical that discusses and highlights, new programs, events and other community points of interest.

Learning Commons Newsletter is a staff periodical that discusses and highlights, new programs, events and other community points of interest.

Learning Commons Newsletter is a staff periodical that discusses and highlights new programs, events and other community points of interest.

Learning Commons Newsletter is a staff periodical that discusses and highlights new programs, events and other community points of interest.

Learning Commons Newsletter is a staff periodical that discusses and highlights new programs, events and other community points of interest.

Learning Commons Newsletter is a staff periodical that discusses and highlights new programs, events and other community points of interest.

Learning Commons Newsletter is a staff periodical that discusses and highlights new programs, events and other community points of interest.